Genetic polymorphism of inter-alpha-trypsin-inhibitor (ITI): Formal genetic and linkage analyses

@article{Luckenbach1991GeneticPO,
  title={Genetic polymorphism of inter-alpha-trypsin-inhibitor (ITI): Formal genetic and linkage analyses},
  author={Christine Luckenbach and Jost K{\"o}mpf and Horst Ritter},
  journal={Human Genetics},
  year={1991},
  volume={87},
  pages={89-90}
}
SummaryThe polymorphism of inter-alpha-trypsin-inhibitor, ITI, was demonstrated by isoelectric focusing in agarose gels (pH 5–8) followed by protein blotting and immunoassay. Segregation in 239 families with 677 children is consistent with the formal hypothesis that there are two common codominant alleles, ITI*1, ITI*2, and one rare codominant allele, ITI*3, at an autosomal locus ITI. Allele frequencies were calculated as ITI*1=0.600, ITI*2=0.393, ITI*3=0.007. Linkage analysis with 36 markers… CONTINUE READING
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White-cell enzymes: factor XI I I A (F13A), fucosidase (FUCA), malic enzyme, mitochondrial (ME2). The z-score values for ITI and these markers were calculated using the tables

Maynard-Smith
  • R e f e r e n c e s Maynard-Smith S, Penrose LS, Smith CAB
  • 1961