Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China.

@article{Zhou2004GeneticPI,
  title={Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China.},
  author={Min Zhou and Shao-guang Huang and Huan-ying Wan and Biao Li and Wei-wu Deng and Min Li},
  journal={Chinese medical journal},
  year={2004},
  volume={117 10},
  pages={1481-4}
}
BACKGROUND There are many candidate genes for chronic obstructive pulmonary disease (COPD). Matrix metalloproteinase-9 (MMP-9) plays an essential role in tissue remodeling and repair associated with development of COPD. In this study we investigated the correlation between MMP-9 gene polymorphism and COPD susceptibility in the Han population of South China. METHODS We examined the frequency of polymorphic genotypes of the MMP-9 promoter (-1562C/T) in 100 COPD patients and 98 healthy smokers… CONTINUE READING

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International journal of chronic obstructive pulmonary disease • 2017

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