Genetic polymorphism in hOGG1 is associated with triple-negative breast cancer risk in Chinese Han women.

@article{Xie2013GeneticPI,
  title={Genetic polymorphism in hOGG1 is associated with triple-negative breast cancer risk in Chinese Han women.},
  author={Hui Xie and Kai Xia and Hui Rong and Xiaoxiang Chen},
  journal={Breast},
  year={2013},
  volume={22 5},
  pages={707-12}
}
8-hydroxy-2'-deoxyguanine (8-OHdG), a typical product of oxidative stress-induced DNA damage, can cause a G-T transversion during DNA replication if it is not removed. Human 8-oxoguanine glycosylase 1 (hOGG1), a key DNA repair gene, recognizes and excises 8-OHdG from damaged DNA accurately; however, a c.977C>G (Ser326Cys) polymorphism in hOGG1 can inhibit the gene's ability to remove 8-OHdG. The aim of present study was to investigate the association between the c.977C>G polymorphism in hOGG1… CONTINUE READING
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