Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.

  title={Genetic polymorphism in N-Acetyltransferase (NAT): Population distribution of NAT1 and NAT2 activity.},
  author={Katy Walker and Gary L. Ginsberg and Dale B. Hattis and Douglas O. Johns and Kathryn Z. Guyton and Babasaheb Sonawane},
  journal={Journal of toxicology and environmental health. Part B, Critical reviews},
  volume={12 5-6},
N-Acetyltransferases (NAT) are key enzymes in the conjugation of certain drugs and other xenobiotics with an arylamine structure. Polymorphisms in NAT2 have long been recognized to modulate toxicity produced by the anti-tubercular drug isoniazid, with molecular epidemiologic studies suggesting a link between acetylator phenotype and increased risk for bladder cancer. Recent evidence indicates that the other major NAT isozyme, NAT1, is also polymorphic. The current analysis characterizes the… CONTINUE READING


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