Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar.

@article{Gonzalez1995GeneticPA,
  title={Genetic polymorphism and cancer susceptibility: fourteenth Sapporo Cancer Seminar.},
  author={Frank J. Gonzalez},
  journal={Cancer research},
  year={1995},
  volume={55 3},
  pages={710-5}
}
It has long been recognized since the early studies in Japan by Yamagiwa and Ichikawa with coal tar-induced carcinogenesis that exposure to environmental and dietary chemicals are likely to be responsible for the vast majority of human cancers. A large number of enzymes participate in both activation and inactivation pathways of carcinogen metabolism. These enzymes mainly function in xenobiotic metabolism and are not thought to play critical roles in metabolism of endogenous chemicals such as… CONTINUE READING