Genetic polymorphism across regions of the three open reading frames of “Norwalk-like viruses”

  title={Genetic polymorphism across regions of the three open reading frames of “Norwalk-like viruses”},
  author={J. Vinj{\'e} and J. Green and D. Lewis and C. I. Gallimore and D. Brown and M. Koopmans},
  journal={Archives of Virology},
  • J. Vinjé, J. Green, +3 authors M. Koopmans
  • Published 2000
  • Biology, Medicine
  • Archives of Virology
  • Summary. Genomic characterization of Norwalk-like human caliciviruses (NLVs) originating from outbreaks and sporadic cases of acute gastroenteritis has revealed surprisingly high levels of diversity, even in the RNA polymerase gene, which is anticipated to be highly conserved. Since information on antigenic relationship is limited, due to the lack of a tissue culture system for these viruses, strains mostly are described on the basis of their genetic relatedness. However, the lack of uniformly… CONTINUE READING
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