Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.

@article{PedersenBjergaard2002GeneticPI,
  title={Genetic pathways in therapy-related myelodysplasia and acute myeloid leukemia.},
  author={Jens Pedersen-Bjergaard and Mette Klarskov Andersen and Debes H Christiansen and Claus Nerlov},
  journal={Blood},
  year={2002},
  volume={99 6},
  pages={
          1909-12
        }
}
  • Jens Pedersen-Bjergaard, Mette Klarskov Andersen, +1 author Claus Nerlov
  • Published 2002
  • Medicine
  • Blood
  • Therapy-related acute myeloid leukemia (t-AML) in most cases develops after chemotherapy of other malignancies and shows characteristic chromosome aberrations. Two general types of t-AML have previously been identified. One type is observed after therapy with alkylating agents and characteristically presents as therapy-related myelodysplasia with deletions or loss of the long arms of chromosomes 5 and 7 or loss of the whole chromosomes. The other type is observed after therapy with… CONTINUE READING

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