Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.

  title={Genetic pathways in the evolution of morphologically distinct colorectal neoplasms.},
  author={Masakazu Yashiro and John M. Carethers and Luigi Laghi and Kana Saito and Premysl Slezak and Edgar Jaramillo and Carlos Rubio and Keiichi Koizumi and Kosei Hirakawa and Clement Richard Boland},
  journal={Cancer research},
  volume={61 6},
Colorectal adenomas can be morphologically classified as exophytic or flat. Polypoid cancers and cancers arising de novo (ie., without any adenomatous component) might be the results of genetic progression from exophytic and flat adenomas, respectively. In this study, we examined 94 morphologically distinct neoplastic specimens for mutations in K-RAS and analyzed 10 microsatellite loci tightly linked to the tumor suppressor genes APC, p53, DCC/SMAD4, hMSH2, and hMLH1. K-RAS mutations were… CONTINUE READING
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