Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.

@article{Parisien2019GeneticPA,
  title={Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain.},
  author={Marc Parisien and Alexander Samoshkin and Shannon N. Tansley and Marjo H Piltonen and Loren S. Martin and Nehm{\'e} El-Hachem and Concetta Dagostino and Massimo Allegri and Jeffrey S Mogil and Arkady Khoutorsky and Luda Diatchenko},
  journal={Pain},
  year={2019},
  volume={160 4},
  pages={
          932-944
        }
}
Chronic pain is a debilitating and poorly treated condition whose underlying mechanisms are poorly understood. Nerve injury and inflammation cause alterations in gene expression in tissues associated with pain processing, supporting molecular and cellular mechanisms that maintain painful states. However, it is not known whether transcriptome changes can be used to reconstruct a molecular pathophysiology of pain. In the current study, we identify molecular pathways contributing to chronic pain… CONTINUE READING

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