Genetic origins of low birth weight

@article{Yaghootkar2012GeneticOO,
  title={Genetic origins of low birth weight},
  author={Hanieh Yaghootkar and Rachel M. Freathy},
  journal={Current Opinion in Clinical Nutrition and Metabolic Care},
  year={2012},
  volume={15},
  pages={258–264}
}
  • H. Yaghootkar, R. Freathy
  • Published 1 May 2012
  • Biology, Medicine
  • Current Opinion in Clinical Nutrition and Metabolic Care
Purpose of reviewSmaller size at birth is associated with a higher risk of type 2 diabetes in later life, but the mechanisms behind this association are poorly understood. Genetic variants which influence susceptibility to type 2 diabetes via effects on insulin secretion or action are good candidates for association with birth weight because foetal insulin is a key foetal growth factor. This review will focus on recent progress in identifying associations between common genetic variants and… Expand
Trans-ethnic meta-analysis of genome-wide association studies identifies maternal ITPR1 as a novel locus influencing fetal growth during sensitive periods in pregnancy
TLDR
New light is shed on the role of common maternal genetic variants in the inositol receptor signaling pathway on fetal growth from late second trimester to early third trimester in pregnant women recruited through the NICHD Fetal Growth Studies. Expand
Assessing the Causal Relationship of Maternal Height on Birth Size and Gestational Age at Birth: A Mendelian Randomization Analysis
TLDR
The results demonstrate that the observed association between maternal height and fetal growth measures (i.e., birth length and birth weight) is mainly defined by fetal genetics, and the association betweenaternal height and gestational age is more likely to be causal. Expand
Maternal and Offspring Genetic Risk of Type 2 Diabetes and Offspring Birthweight Among African Ancestry Populations.
TLDR
Maternal and offspring GRS of T2D were independently and differentially associated with offspring birthweight, whereas maternal post-challenge glucose levels showed additive effects with maternal GRS on birthweight. Expand
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
TLDR
Expanded genome-wide association analyses of own BW and offspring BW identified 278 independent association signals influencing BW, and shows that the association between lower BW and higher adult BP is attributable to genetic effects, and not to intrauterine programming. Expand
Distinct genetic backgrounds in quantitative traits preceding type 2 diabetes: one reason for missing heritability.
TLDR
Recognition of preceding prediabetic glycemic thresholds and both their genetic and environmental associations may facilitate and serve as signals for prevention. Expand
Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study.
TLDR
The variant GCK rs1799884 (mm) was associated with a reduction in newborn weight in the miscegenated Brazilian population. Expand
Maternal Profile, Assisted Reproductive Technology, and Perinatal Health Indicators
TLDR
Among aetiology of LBW, macrosomia, SGA and LGA, it is possible to discern between genetic factors, socioeconomic factors, and maternalfoetal factors such as age at maternity, parity, type of birth (vaginal or by Caesarean section-CS-), multiple gestation or origin of the mother. Expand
Parental diabetes and birthweight in 236 030 individuals in the UK Biobank Study
TLDR
Data from the UK Biobank provides the strongest evidence by far that paternal diabetes is associated with lower birthweight, whereas maternal diabetes isassociated with increased birthweight. Expand
Ethnic differences in the relationship between birth weight and type 2 diabetes mellitus in postmenopausal women.
TLDR
Lower birth weight was associated with increased T2D risk in American White and Black post-menopausal women and the inverse association between birth weight and type 2 diabetes mellitus was only apparent in White women, but not Black, Hispanic or Asian women. Expand
DNA Methylation Associated With Diabetic Kidney Disease in Blood-Derived DNA
TLDR
Analysis of DNA methylation, a major epigenetic feature, evaluating methylome-wide loci for association with diabetic kidney disease confirms that methylation sites influence the development of DKD, and may aid risk prediction tools and stimulate research to identify epigenomic therapies which might be clinically useful for this disease. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 48 REFERENCES
Type 2 Diabetes Risk Alleles Are Associated With Reduced Size at Birth
TLDR
The results are in keeping with the fetal insulin hypothesis and provide robust evidence that common disease-associated variants can alter size at birth directly through the fetal genotype. Expand
Examination of Type 2 Diabetes Loci Implicates CDKAL1 as a Birth Weight Gene
TLDR
Association between lower birth weight and type 2 diabetes risk–conferring alleles at the CDKAL1 locus is observed and the same genetic locus that has been identified as a marker for type 1 diabetes in previous studies also influences birth weight. Expand
Absence of Birth-Weight Lowering Effect of ADCY5 and Near CCNL, but Association of Impaired Glucose-Insulin Homeostasis with ADCY5 in Asian Indians
TLDR
The low birth weight in Asian Indians is not even partly explained by genetic variants near CCNL1 and ADCY5 which implies that non-genetic factors may predominate. Expand
HHEX-IDE polymorphism is associated with low birth weight in offspring with a family history of type 1 diabetes.
TLDR
The association of low birth weight and type 2 diabetes risk alleles of the HHEX-IDE locus is confirmed in children of mothers with type 1 diabetes. Expand
Type 2 diabetes TCF7L2 risk genotypes alter birth weight: a study of 24,053 individuals.
TLDR
The first type 2 diabetes-susceptibility allele to be reproducibly associated with birth weight is identified, and the most likely mechanism is that the risk allele reduces maternal insulin secretion, which results in increased maternal glycemia in pregnancy and hence increased offspring birth weight. Expand
Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight
TLDR
It is found that the 9% of Europeans carrying four birth weight–lowering alleles were, on average, 113 g (95% CI 89–137 g) lighter at birth than the 24% with zero or one alleles, similar to that of a mother smoking 4–5 cigarettes per day in the third trimester of pregnancy. Expand
Type 2 diabetes gene TCF7L2 polymorphism is not associated with fetal and postnatal growth in two birth cohort studies
TLDR
The objective of this study was to examine whether T2D gene polymorphism TCF7L2 rs7903146 is associated with growth patterns from fetal life until infancy, and found no evidence for an association between TCF 7L2 genotype and fetal and early postnatal growth. Expand
Genetic influences on the association between fetal growth and susceptibility to type 2 diabetes
The fetal insulin hypothesis proposes that low birth weight and susceptibility to type 2 diabetes (T2D) could both be two phenotypes of the same genotype. Insulin is a key growth factor in utero, andExpand
Do Gene Variants Influencing Adult Adiposity Affect Birth Weight? A Population-Based Study of 24 Loci in 4,744 Danish Individuals
TLDR
24 common variants associated with adult adiposity did not affect or interact with birth weight among Danes suggesting that the effects of these variants predominantly arise in the post-natal life. Expand
Type 2 diabetes risk alleles near ADCY5, CDKAL1 and HHEX-IDE are associated with reduced birthweight
TLDR
A novel association is reported between the fetal ADCY5 type 2 diabetes risk allele and decreased birthweight, and in meta-analyses associations between decreased birth Weight and the type 1 diabetes risk alleles of HHEX-IDE and CDKAL1 are confirmed. Expand
...
1
2
3
4
5
...