Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome.

@article{Westers2008GeneticOC,
  title={Genetic or chemical protease inhibition causes significant changes in the Bacillus subtilis exoproteome.},
  author={Lidia Westers and Helga Westers and Geeske Zanen and Haike Antelmann and Michael Hecker and David Noone and Kevin M Devine and Jan Maarten van Dijl and Wim J Quax},
  journal={Proteomics},
  year={2008},
  volume={8 13},
  pages={2704-13}
}
Bacillus subtilis is a prolific producer of enzymes and biopharmaceuticals. However, the susceptibility of heterologous proteins to degradation by (extracellular) proteases is a major limitation for use of B. subtilis as a protein cell factory. An increase in protein production levels has previously been achieved by using either protease-deficient strains or addition of protease inhibitors to B. subtilis cultures. Notably, the effects of genetic and chemical inhibition of proteases have thus… CONTINUE READING

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