Genetic neuropathology of Parkinson's disease.

  title={Genetic neuropathology of Parkinson's disease.},
  author={Mark R Cookson and John S. Hardy and Patrick A. Lewis},
  journal={International journal of clinical and experimental pathology},
  volume={1 3},
Parkinson's disease (PD) has long been considered to be a sporadic entity, perhaps with an environmental etiology. However, recent genetic discoveries have challenged this view, as there are many families with diseases of Mendelian inheritance that clinically resemble PD. Here, we will review in detail the neuropathological data relating to familial cases of PD. We will discuss the complicated relationships between the genetically defined cases and the two key pathological events seen in PD… CONTINUE READING


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