Genetic neurodegenerative diseases: the human illness and transgenic models.

  title={Genetic neurodegenerative diseases: the human illness and transgenic models.},
  author={Donald L. Price and Sangram S. Sisodia and David R Borchelt},
  volume={282 5391},
Review The neurodegenerative disorders, a heterogeneous group of chronic progressive diseases, are among the most puzzling and devastating illnesses in medicine. Some of these disorders, such as Alzheimer's disease, amyotrophic lateral sclerosis, the prion diseases, and Parkinson's disease, can occur sporadically and, in some instances, are caused by inheritance of gene mutations. Huntington's disease is acquired in an entirely genetic manner. Transgenic mice that express disease-causing genes… CONTINUE READING

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