Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu.

@article{Bell1992GeneticMO,
  title={Genetic monitoring of human polymorphic cancer susceptibility genes by polymerase chain reaction: application to glutathione transferase mu.},
  author={Douglas A. Bell and Claudia L. Thompson and J. Ben Taylor and C. Ryan Miller and Frederica P. Perera and Ling-ling Hsieh and George W. Lucier},
  journal={Environmental Health Perspectives},
  year={1992},
  volume={98},
  pages={113 - 117}
}
Several genes involved in the metabolism of carcinogens have been found to be polymorphic in human populations and are associated with increased risk of cancer at some sites. This study focuses on the polymorphic enzyme glutathione transferase mu (GT mu). Smokers with low lymphocyte GT mu activity are at an approximately 2-fold higher risk for lung cancer and an approximately 3-fold higher risk for stomach and colon adenocarcinomas. Recent cloning and sequencing of the GST1 gene has allowed the… 

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