Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors.

@article{Brat2003GeneticMO,
  title={Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors.},
  author={Daniel J. Brat and B. Devinder Kaur and Erwin G Van Meir},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2003},
  volume={8},
  pages={d100-16}
}
Angiogenesis is required for the development and biologic progression of infiltrative astrocytomas and takes the form of "microvascular hyperplasia" in glioblastoma multiforme, the most malignant astrocytoma. This pathologic term refers to an abnormal vascular proliferation that is often associated with necrosis and likely originates in hypoxic zones. Both the physiologic response to hypoxia and genetic alterations contribute to this process. The presence of hypoxic regions within an expanding… CONTINUE READING

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