Genetic modification of pigs as organ donors for xenotransplantation

@article{Klymiuk2010GeneticMO,
  title={Genetic modification of pigs as organ donors for xenotransplantation},
  author={Nikolai Klymiuk and Bernhard Aigner and Gottfried Brem and Eckhard Wolf},
  journal={Molecular Reproduction and Development},
  year={2010},
  volume={77}
}
Transgenic pigs are promising donor organisms for xenotransplantation as they share many anatomical and physiological characteristics with humans. The most profound barrier to pig‐to‐primate xenotransplantation is the rejection of the grafted organ by a cascade of immune mechanisms commonly referred to as hyperacute rejection (HAR), acute humoral xenograft rejection (AHXR), immune cell‐mediated rejection, and chronic rejection. Various strategies for the genetic modification of pigs facilitate… 
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