Genetic modification of corneal neovascularization in Dstn corn1 mice

Abstract

Mutations in the gene for destrin (Dstn), an actin depolymerizing factor, lead to corneal abnormalities in mice. A null mutation in Dstn, termed Dstn corn1 , isolated and maintained in the A.BY background (A.BY Dstn corn1 ), results in corneal epithelial hyperproliferation, inflammation, and neovascularization. We previously reported that neovascularization… (More)
DOI: 10.1007/s00335-013-9468-9

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