Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis

@article{MirColl2016GeneticMR,
  title={Genetic models rule out a major role of beta cell glycogen in the control of glucose homeostasis},
  author={Joan Mir-Coll and Jordi Dur{\'a}n and Felipe Slebe and Mar Garc{\'i}a-Rocha and Ram{\'o}n Morell Gomis and Rosa M. Gasa and Joan J. Guinovart},
  journal={Diabetologia},
  year={2016},
  volume={59},
  pages={1012-1020}
}
Glycogen accumulation occurs in beta cells of diabetic patients and has been proposed to partly mediate glucotoxicity-induced beta cell dysfunction. However, the role of glycogen metabolism in beta cell function and its contribution to diabetes pathophysiology remain poorly understood. We investigated the function of beta cell glycogen by studying glucose homeostasis in mice with (1) defective glycogen synthesis in the pancreas; and (2) excessive glycogen accumulation in beta cells. Conditional… CONTINUE READING
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