Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation

@article{Zuntini2010GeneticMO,
  title={Genetic models of osteochondroma onset and neoplastic progression: evidence for mechanisms alternative to EXT genes inactivation},
  author={Monia Zuntini and Elena Pedrini and Alessandro Parra and Federica Sgariglia and Filomena Valentina Gentile and Mat{\'i}as Pandolfi and Marco Alberghini and Luca Sangiorgi},
  journal={Oncogene},
  year={2010},
  volume={29},
  pages={3827-3834}
}
Osteochondroma, the most common benign bone tumor, may occur as a sporadic lesion or as multiple neoplasms in the context of multiple osteochondromas syndrome. The most severe complication is malignant transformation into peripheral secondary chondrosarcoma. Although both benign conditions have been linked to defects in EXT1 or EXT2 genes, contradictory reports are present in the literature regarding the requirement of their biallelic inactivation for osteochondroma development. A major… CONTINUE READING