Genetic metabolic polymorphisms and the risk of cancer: a review of the literature.

  title={Genetic metabolic polymorphisms and the risk of cancer: a review of the literature.},
  author={A D'errico and Emanuela Taioli and X Chen and Paolo Vineis},
  journal={Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals},
  volume={1 3},
Abstract The purpose of this paper is to systematically analyse the design and results of epidemiological studies on the association between various types of cancer (lung, bladder, breast, colon, stomach) and four genetically-based metabolic polymorphisms, involved in the metabolism of several carcinogens (glutathione-S-transferase M1, debrisoquine hydroxylase, N acetyltransferase, aryl hydrocarbon hydroxylase). These inherited polymorphisms usually cause modifications in the quality or… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 65 extracted citations


Publications referenced by this paper.
Showing 1-10 of 118 references

Distribution of composite CYPlAl genotypes in AfricanAmericans, Africans and Caucasians

  • E. Tmu
  • Human Heridity,
  • 1996

1995a) A CYPlAl restriction fragment length polymorphism is associated with breast cancer in African-American women

  • S J.
  • Cancer Research,
  • 1995

Lung cancer risk in African-Americans in relation to a racespecific CYPlAl polymorphism

  • J R.
  • Cancer Research,
  • 1995

Slow Nacetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer

  • A. RIW, D. M. A. WWE
  • Human Molecular Genetics
  • 1995

The hemebinding region polymorphism of cytochrome P 4501 A 1 ( CYPlAlI , rather than the Rsal polymorphism of P 45011 E 1 ( CYPIIEl ) , is associated with lung cancer in Rio de Janeiro

  • Cancer Epidemiology , Biomarkers and Prevention
  • 1995

A racespecific genetic polymorphism in the CYPlAl gene is not associated with lung cancer in African Americans

  • K. T. Kuw, J. K. AH Spm WIENCKE, R. M.
  • New England Journal of Medicine
  • 1994

Similar Papers

Loading similar papers…