Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells.

Abstract

A variant of the MPC 11 cell line, M 311, produces a short immunoglobulin heavy chain. When compared with the parental gamma 2b heavy chain, M 311 was found to have a carboxyl terminal deletion comprising the CH3 domain. The COOH-terminal cyanogen bromide (CNBr) cleavage fragment of M 311 is identical to a corresponding segment ofa parental heavy chain CNBr… (More)

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@article{Kenter1979GeneticMA, title={Genetic mechanism accounting for precise immunoglobulin domain deletion in a variant of MPC 11 myeloma cells.}, author={Amy L. Kenter and Barbara K. Birshtein}, journal={Science}, year={1979}, volume={206 4424}, pages={1307-9} }