Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.

  title={Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.},
  author={Alan Y. Deng and Howard Dene and Michal Pravenec and John P. Rapp},
  journal={The Journal of clinical investigation},
  volume={93 6},
The endothelin system, consisting of a series of potent vasoconstrictor peptides and their receptors, is potentially important in the control of blood pressure. We found that the gene coding for endothelin-2 (ET2), also known as vasoctive intestine peptide, cosegregated strongly with systolic blood pressure in a F2 population [F2(S x LEW)] derived from a cross of the Dahl salt-sensitive (S) rat and the Lewis (LEW/NCrlBR) (LEW) rat. The ET2 locus was assigned to rat chromosome 5. The testis… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 48 extracted citations


Publications referenced by this paper.
Showing 1-10 of 40 references

Genetic analysis of a 2 - adrenergic receptors and blood pressure using Dahl salt - sensitive rats

  • E. F. Fritsch
  • J . Hypertens .
  • 1994

A new genetic locus cosegregating with blood pressure in F 2 progeny obtained from stroke - prone spontaneously hypertensive rats and Wistar - Kyoto rats

  • K. Lindpaintner, P. Hilbert, D. Ganten, B. Nadal-Ginard, T. Inagami, H. Iwai
  • 1993

Dahl ' s salt - resistant normotensive rat has mutations in cytochromic p 450 ( 1 I ) , but the salt - sensitive hypertensive rat does not

  • R. C. Elston, L. D. Tran, R. M. Siervogel
  • J . Biol . Chem .
  • 1993

Detecting marker - QTL linkage and estimating QTL gene effect and map location using a standard genetic map

  • O.-E. Brodde
  • 1993

Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats

  • D. L. Ely, H. Daneshvar, M. E. Turner, M. L. Johnson
  • Nature Genet .
  • 1993

Genetic map of seven polymorphic markers comprising a single linkage group on rat chromosome 5

  • Y. Wang, H. Dene, J. P. Rapp
  • Mammal . Genome .
  • 1993

Linkage of 1 I 1 P - hydroxylase mutations with altered steroid biosynthesis and blood pressure in the Dahl rat

  • H. Kurihara, S. Kimura, +5 authors T. Masaki
  • Nature Genet .
  • 1993

Molecular genetics of the SAgene : cosegregation with hypertension and mapping to rat chromosome 1

  • T. Katsuya, J. Higaki, +4 authors T. Ogihara
  • J . Hypertens .
  • 1993

Similar Papers

Loading similar papers…