Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.

@article{Deng1994GeneticMO,
  title={Genetic mapping of two new blood pressure quantitative trait loci in the rat by genotyping endothelin system genes.},
  author={Alan Y. Deng and Howard Dene and Michal Pravenec and John P. Rapp},
  journal={The Journal of clinical investigation},
  year={1994},
  volume={93 6},
  pages={2701-9}
}
The endothelin system, consisting of a series of potent vasoconstrictor peptides and their receptors, is potentially important in the control of blood pressure. We found that the gene coding for endothelin-2 (ET2), also known as vasoctive intestine peptide, cosegregated strongly with systolic blood pressure in a F2 population [F2(S x LEW)] derived from a cross of the Dahl salt-sensitive (S) rat and the Lewis (LEW/NCrlBR) (LEW) rat. The ET2 locus was assigned to rat chromosome 5. The testis… CONTINUE READING

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