Genetic mapping of adrenergic receptor genes in humans

@article{Hoehe2004GeneticMO,
  title={Genetic mapping of adrenergic receptor genes in humans},
  author={M. R. Hoehe and B. Otterud and W T Hsieh and M M Martinez and D. Stauffer and John J. Holik and Wade H. Berrettini and William Byerley and Elliot S. Gershon and J. M. Lalouel and M. Leppert},
  journal={Journal of Molecular Medicine},
  year={2004},
  volume={73},
  pages={299-306}
}
We have genetically mapped the genes encoding four human adrenergic receptors (ARs) of subtypes α1C, α2A, α2B, and β1, which are prototypic G protein coupled receptors that mediate the physiological effects of neurotransmitters, hormones, and drugs. We placed these genes onto the Cooperative Human Linkage Center (CHLC) and Genethon framework maps, within confidence intervals with greater than 1000∶1 odds. With multipoint analysis the α1C gene (locus ADRA1C) mapped to the interval between NEFL… 
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The pharmacogenomics of adrenergic receptors have proven immense variability in candidate genes amongst populations that lead to different drug responses for epinephrine, dexmedetomidine, and salbutamol is highlighted.
Association of beta 1-adrenergic receptor gene polymorphisms with left ventricular hypertrophy in human essential hypertension.
The CAREGENE study: polymorphisms of the beta1-adrenoceptor gene and aerobic power in coronary artery disease.
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Ser49gly and haplotype combinations of Ser49Gly and Gly389Arg of the beta(1)AR gene are associated with aerobic power, but not with the response to physical training in patients with CAD included in the CAREGENE study.
Noradrenergic genes polymorphisms and response to methylphenidate in children with ADHD
TLDR
The meta-analysis results indicate that the noradrenergic gene polymorphisms may impact MPH response, and the NET rs28386840 is linked to improved MPH response in ADHD children.
Beta1-adrenergic receptor polymorphisms and clinical efficacy of betaxolol hydrochloride in normal volunteers.
Understanding the Role of Novel Gene-Environmental and Gene-Gene Interactions in the Pathogenesis of Age Related Macular Degeneration
TLDR
SNPs in NOS2A are associated with increased risk for AMD and might modulate the smoking effect on AMD and the inverse association of AMD and HRT is dependent on SNP genotypes in ESR1 and ESR2 and independent of the ARMS2 locus.
Candidate Genes in Hypertension
TLDR
This chapter exposes the genetic markers of EH and their expression related to lifestyle through several strategies such as investigation of specific candidate genes, genome-wide searches, use of intermediate phenotypes, comparative genomics and a combination of these methods.
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References

SHOWING 1-10 OF 79 REFERENCES
Precise Mapping of the Brain α2-Adrenergic Receptor Gene within Chromosome 4p16
TLDR
The investigation of families carrying recombinant chromosomes, pulsed-field analysis, and genomic walking mapped the ADRAC2 gene adjacent to D4S81, 500 kb proximal to the HD gene, and newly defined microsatellites at the ADrAC2 locus facilitate the identification of any defect caused by this gene.
Chromosomal organization of adrenergic receptor genes.
TLDR
The alpha 1- AR gene is mapped to chromosome 5q32----q34, the same position as beta 2-AR, and the beta 1-AR gene to chromosome 10q24----q26, the region where alpha 2- AR is located, as well as the sequence similarity that exists among all the ARs.
Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution.
Genomic organization and expression of the human alpha 1B-adrenergic receptor.
Genetic linkage of the human gene for phenylethanolamine N-methyltransferase (PNMT), the adrenaline-synthesizing enzyme, to DNA markers on chromosome 17q21-q22.
TLDR
The human chromosome region 17q21-22 identified here to harbour the PNMT gene may be syntenic to the chromosomal region in the stroke-prone spontaneously hypertensive rat (SHR-SP), recently linked to blood-pressure regulation.
Expansion of the alpha 2-adrenergic receptor family: cloning and characterization of a human alpha 2-adrenergic receptor subtype, the gene for which is located on chromosome 2.
Pharmacologic, biochemical, and genetic analyses have demonstrated the existence of multiple alpha 2-adrenergic receptor (alpha 2AR) subtypes. We have cloned a human alpha 2AR by using the polymerase…
Molecular characterization of the human beta 3-adrenergic receptor.
TLDR
Novel beta-AR agonists having high thermogenic, antiobesity, and antidiabetic activities in animal models are among the most potent stimulators of the beta 3-AR.
Cloning of the cDNA for the human beta 1-adrenergic receptor.
TLDR
RNA blot analysis indicates a message of 2.5 kilobases in rat tissues, with a pattern of tissue distribution consistent with beta 1AR binding, which suggests that the avian gene encoding beta AR and the human gene encodingbeta 1AR evolved from a common ancestral gene.
A biallelic DNA polymorphism of the human beta-2-adrenergic receptor detected by Ban I-Adrbr-2.
TLDR
The human beta-2-adrenergic receptor gene has been assigned to chromosome 5q31-32 andCodominant segregation in 3 families with 2 generations is found.
Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.
TLDR
The gene for the human platelet alpha 2-adrenergic receptor has been cloned with oligonucleotides corresponding to the partial amino acid sequence of the purified receptor, and two related genes have been identified by low stringency Southern blot analysis.
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