Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23.

@article{Bachinski2005GeneticMO,
  title={Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23.},
  author={Linda L. Bachinski and S E Olufemi and Xiaojun Zhou and Chih-Chieh Wu and Linwah Yip and Sanjay Shete and Guillermina Lozano and Christopher I. Amos and Louise C. Strong and Ralf Krahe},
  journal={Cancer research},
  year={2005},
  volume={65 2},
  pages={427-31}
}
Li-Fraumeni syndrome (LFS) is a clinically and genetically heterogeneous inherited cancer syndrome. Most cases ( approximately 70%) identified and characterized to date are associated with dominantly inherited germ line mutations in the tumor suppressor gene TP53 (p53) in chromosome 17p13.1. In a subset of non-p53 patients with LFS, CHEK2 in chromosome… CONTINUE READING