Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2.

@article{Hahn2004GeneticMO,
  title={Genetic mapping of a Ptch1-associated rhabdomyosarcoma susceptibility locus on mouse chromosome 2.},
  author={Heidi Ann Hahn and Frauke Nitzki and Tatjana Schorban and Bernhard Hemmerlein and David W Threadgill and Michael Rosemann},
  journal={Genomics},
  year={2004},
  volume={84 5},
  pages={
          853-8
        }
}
Mutations in the Patched (Ptch1) gene are responsible for various familial and sporadic cancers. Ptch1(neo67/+) mice, in which exons 6 and 7 are deleted, show genetic background-dependent susceptibility to the development of muscle tumors resembling human rhabdomyosarcoma (RMS); BALB/c (BALB) is a susceptible strain whereas C57BL/6 (B6) shows resistance. A genome-wide linkage analysis was carried out using Ptch1(neo67/+)mice produced from B6 x (BALB x B6) backcrosses to identify loci involved… CONTINUE READING
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