Genetic mapping in the presence of genotyping errors.

@article{Cartwright2007GeneticMI,
  title={Genetic mapping in the presence of genotyping errors.},
  author={Dustin A. Cartwright and Michela Troggio and Riccardo Velasco and Alexander Gutin},
  journal={Genetics},
  year={2007},
  volume={176 4},
  pages={2521-7}
}
Genetic maps are built using the genotypes of many related individuals. Genotyping errors in these data sets can distort genetic maps, especially by inflating the distances. We have extended the traditional likelihood model used for genetic mapping to include the possibility of genotyping errors. Each individual marker is assigned an error rate, which is inferred from the data, just as the genetic distances are. We have developed a software package, called TMAP, which uses this model to find… CONTINUE READING
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