Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization.

@article{Dagarag2004GeneticMO,
  title={Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and telomere length stabilization.},
  author={Mirabelle D Dagarag and Tandik Evazyan and Nagesh Mukunda Rao and Rita B. Effros},
  journal={Journal of immunology},
  year={2004},
  volume={173 10},
  pages={6303-11}
}
A large proportion of the CD8(+) T cell pool in persons chronically infected with HIV consists of cells that show features of replicative senescence, an end stage characterized by irreversible cell cycle arrest, multiple genetic and functional changes, and shortened telomeres. The objective of our research was to determine whether constitutive expression of the gene for the human telomerase (hTERT) can prevent senescence-induced impairments in human virus-specific CD8(+) T cells, particularly… CONTINUE READING