Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse

  title={Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse},
  author={P. H. Seeburg and Frank N. Single and Thomas Kuner and Miyoko Higuchi and Rolf Sprengel},
  journal={Brain Research},
Recent advances in the study of AMPA receptors.
Recent advances of studies on AMPA receptor functions are reviewed, finding that relative low level of edited GluR2 subunit expression is likely responsible for motoneuronal death in ALS and conversion to Ca(2+)-permeable receptors induces morphological and functional changes.
AMPA receptor ligand-binding domain: Site-directed mutagenesis study of ligand-receptor interactions
Characterization of ligand-binding domains of GluR-B and GLUR-D glutamate receptor subunits expressed as periplasmic proteins in Eschericia coli and implications for redox modulation of glutamate receptors are presented.
Receptor, Transporter and Ion Channel Diseases
Ion channels reflect an important but still very new mechanism of disease, first formalized in 1989 with the discovery of mutations in the CFTR ion channel gene causing cystic fibrosis, and are recognized to cover the gamut of medical disciplines and to cause significant pathology in virtually every organ system.
Challenges for and current status of research into positive modulators of AMPA receptors
The challenges involved in identifying a chemically distinct series of AMPA receptor positive modulators are outlined, addressing the challenges created by the heterogeneity of the AMPA receptors populations and the development of structure‐activity relationships driven by homomeric, recombinant systems on high‐throughput platforms are addressed.
Excitotoxicity and ALS: What is unique about the AMPA receptors expressed on spinal motor neurons?
  • Y. KawaharaS. Kwak
  • Biology
    Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
  • 2005
This review focuses on recent progress on the molecular dynamics of AMPA receptors and discusses the pathophysiology of selective motor neuron death mediated by AM PA receptors in individuals affected with sporadic ALS.
Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus
These results suggest that the Mg2+ block in the dentate gyrus regulates hippocampal spatial information processing by attenuating activity-dependent synaptic potentiation in the dentist's gyrus.
The ADAR protein family
A review on the current knowledge regarding the ADAR protein family, including evolutionary history, key structural features, localization, function and mechanism is presented.


Single-Channel Properties of Recombinant AMPA Receptors Depend on RNA Editing, Splice Variation, and Subunit Composition
It is suggested that the single-channel conductance of certain recombinant AMPA receptors may be determined by the expression of edited GluR2 subunits in neurons.
The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
The architecture of the pore establishes the physical principles underlying selective K+ conduction, which promotes ion conduction by exploiting electrostatic repulsive forces to overcome attractive forces between K+ ions and the selectivity filter.
Control by asparagine residues of calcium permeability and magnesium blockade in the NMDA receptor.
AMPA and NMDA receptor channels contain common structural motifs in their TM2 segments that are responsible for some of their ion selectivity and conductance properties.