Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse
@article{Seeburg2001GeneticMO, title={Genetic manipulation of key determinants of ion flow in glutamate receptor channels in the mouse}, author={P. H. Seeburg and Frank N. Single and Thomas Kuner and Miyoko Higuchi and Rolf Sprengel}, journal={Brain Research}, year={2001}, volume={907}, pages={233-243} }
63 Citations
Recent advances in the study of AMPA receptors.
- BiologyNihon yakurigaku zasshi. Folia pharmacologica Japonica
- 2003
Recent advances of studies on AMPA receptor functions are reviewed, finding that relative low level of edited GluR2 subunit expression is likely responsible for motoneuronal death in ALS and conversion to Ca(2+)-permeable receptors induces morphological and functional changes.
AMPA receptor ligand-binding domain: Site-directed mutagenesis study of ligand-receptor interactions
- Biology, Chemistry
- 2003
Characterization of ligand-binding domains of GluR-B and GLUR-D glutamate receptor subunits expressed as periplasmic proteins in Eschericia coli and implications for redox modulation of glutamate receptors are presented.
Regulation of ion channel/neurotransmitter receptor function by RNA editing
- BiologyCurrent Opinion in Neurobiology
- 2003
Receptor, Transporter and Ion Channel Diseases
- Biology
- 2006
Ion channels reflect an important but still very new mechanism of disease, first formalized in 1989 with the discovery of mutations in the CFTR ion channel gene causing cystic fibrosis, and are recognized to cover the gamut of medical disciplines and to cause significant pathology in virtually every organ system.
Challenges for and current status of research into positive modulators of AMPA receptors
- BiologyBritish journal of pharmacology
- 2010
The challenges involved in identifying a chemically distinct series of AMPA receptor positive modulators are outlined, addressing the challenges created by the heterogeneity of the AMPA receptors populations and the development of structure‐activity relationships driven by homomeric, recombinant systems on high‐throughput platforms are addressed.
Excitotoxicity and ALS: What is unique about the AMPA receptors expressed on spinal motor neurons?
- BiologyAmyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
- 2005
This review focuses on recent progress on the molecular dynamics of AMPA receptors and discusses the pathophysiology of selective motor neuron death mediated by AM PA receptors in individuals affected with sporadic ALS.
Impaired NMDA receptor function in mouse olfactory bulb neurons by tetracycline-sensitive NR1 (N598R) expression.
- BiologyBrain research. Molecular brain research
- 2001
Enhanced stability of hippocampal place representation caused by reduced magnesium block of NMDA receptors in the dentate gyrus
- Biology, PsychologyMolecular Brain
- 2014
These results suggest that the Mg2+ block in the dentate gyrus regulates hippocampal spatial information processing by attenuating activity-dependent synaptic potentiation in the dentist's gyrus.
The ADAR protein family
- BiologyGenome Biology
- 2012
A review on the current knowledge regarding the ADAR protein family, including evolutionary history, key structural features, localization, function and mechanism is presented.
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