Genetic linkage studies for adjuvant arthritis-linked quantitative trait loci

Abstract

Adjuvant arthritis (AA) serves as an excellent model for human rheumatoid arthritis. AA is readily inducible in certain rat strains, but not in others. Susceptibility/resistance to AA is determined by multiple factors. Among the genetic factors, both MHC and nonMHC genes contribute to arthritis susceptibility, and specific quantitative trait loci show association with the severity of the disease. Differential T-cell proliferative and cytokine responses, as well as antibody responses, to heat-shock proteins are evident when comparing AA-susceptible and AA-resistant rats. In addition, neuroendocrine factors and the housing environment can further modulate arthritis susceptibility/severity in particular rat strains.

2 Figures and Tables

Cite this paper

@inproceedings{Kim2009GeneticLS, title={Genetic linkage studies for adjuvant arthritis-linked quantitative trait loci}, author={Eugene Y. Kim and Kamal D. Moudgil}, year={2009} }