Genetic linkage of Werner's syndrome to five markers on chromosome 8

@article{Goto1992GeneticLO,
  title={Genetic linkage of Werner's syndrome to five markers on chromosome 8},
  author={M. Goto and M. Rubenstein and J. Weber and K. Woods and D. Drayna},
  journal={Nature},
  year={1992},
  volume={355},
  pages={735-738}
}
WERNER'S syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing1–3. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common3–5. The WS mutation has pleiotropic effects, and patients and their cells show many differences compared with normals5. Despite extensive study of the clinical and biochemical features of this disorder, the primary… Expand
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4
5
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References

SHOWING 1-10 OF 17 REFERENCES
Werner’s Syndrome and Human Aging
  • 46
Construction of a genetic linkage map in man using restriction fragment length polymorphisms.
  • 6,963
  • PDF
Easy calculations of lod scores and genetic risks on small computers.
  • 1,515
...
1
2
...