Genetic linkage of Werner's syndrome to five markers on chromosome 8

  title={Genetic linkage of Werner's syndrome to five markers on chromosome 8},
  author={M. Goto and M. Rubenstein and J. Weber and Kathryn Woods and D. Drayna},
  • M. Goto, M. Rubenstein, +2 authors D. Drayna
  • Published 1992
  • Biology, Medicine
  • Nature
  • WERNER'S syndrome (WS) is a rare autosomal recessive disease in which the affected individuals display symptoms of premature ageing1–3. The substantial phenotypic overlap between WS and normal ageing indicates that these two conditions may have pathogenetic mechanisms in common3–5. The WS mutation has pleiotropic effects, and patients and their cells show many differences compared with normals5. Despite extensive study of the clinical and biochemical features of this disorder, the primary… CONTINUE READING
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