Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.

@article{Dunlop1990GeneticLM,
  title={Genetic linkage map of six polymorphic DNA markers around the gene for familial adenomatous polyposis on chromosome 5.},
  author={Malcolm G Dunlop and Andrew H. Wyllie and Yusuke Nakamura and Catherine M. Steel and Harlan J. Evans and R. L. White and Cameron C Bird},
  journal={American journal of human genetics},
  year={1990},
  volume={47 6},
  pages={982-7}
}
A genetic linkage map of six polymorphic DNA markers close to the gene (APC) for familial adenomatous polyposis (FAP) on chromosome 5q is reported. One hundred fifty-five typed members of nine FAP kindred provided more than 90 meioses for linkage analysis. A number of crucial recombination events have been identified which are informative at three or more loci, allowing confident ordering of parts of the map. There was no evidence of genetic heterogeneity, with all families showing linkage of… CONTINUE READING

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