Genetic linkage analysis of Canadian spinal muscular atrophy kindreds using flanking microsatellite 5q13 polymorphisms

Abstract

The spinal muscular atrophies (SMA) are among the most common autosomal recessive disorders. We have performed linkage analysis using both standard restriction fragment length polymorphisms (RFLPs) as well as microsatellite polymorphisms [Ca(n)] on 49 Canadian SMA families (types 1, 2, and 3) that both flank and are linked to SMA. The closest SMA linkage… (More)
DOI: 10.1007/BF00217448

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@article{Mackenzie1993GeneticLA, title={Genetic linkage analysis of Canadian spinal muscular atrophy kindreds using flanking microsatellite 5q13 polymorphisms}, author={Alex E Mackenzie and Natalie T Roy and Anne Besner and Gabrielle Mettler and Pierre Jacob and R. G. Korneluk and Linda C. Surh}, journal={Human Genetics}, year={1993}, volume={90}, pages={501-504} }