Genetic lineage tracing defines myofibroblast origin and function in the injured heart

@inproceedings{Kanisicak2016GeneticLT,
  title={Genetic lineage tracing defines myofibroblast origin and function in the injured heart},
  author={Onur Kanisicak and Hadi Khalil and Malina J. Ivey and Jason Karch and Bryan D. Maliken and Robert Nathan Correll and Matthew J. Brody and Suh-Chin J. Lin and Bruce J. Aronow and Michelle D. Tallquist and Jeffery D Molkentin},
  booktitle={Nature communications},
  year={2016}
}
Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease. Myofibroblasts remain a poorly defined cell type in terms of their origins and functional effects in vivo. Here we generate Postn (periostin) gene-targeted mice containing a tamoxifen-inducible Cre for cellular lineage-tracing analysis. This Postn allele identifies essentially all myofibroblasts within the heart and… CONTINUE READING

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