Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia

  title={Genetic investigation of chromosome 5q GABAA receptor subunit genes in schizophrenia},
  author={Tracey L. Petryshen and Frank A. Middleton and A R Tahl and Graham Rockwell and Shaun M Purcell and Kimberly A. Aldinger and Anna Nm Kirby and Christopher P. Morley and Lindsay McGann and Karen L. Gentile and Skye G Waggoner and Hilda Maria Freitas Medeiros and C{\'e}lia Carvalho and Ant{\^o}nio da Silva Mac{\^e}do and Margot Albus and Wolfgang Maier and M{\'a}ty{\'a}s Trixler and Peter Eichhammer and Sibylle G. Schwab and Dieter D B Wildenauer and Maria Helena Pinto de Azevedo and Michele T. Pato and Carlos N. Pato and Mark J. Daly and Pamela Sklar},
  journal={Molecular Psychiatry},
We previously performed a genome-wide linkage scan in Portuguese schizophrenia families that identified a risk locus on chromosome 5q31–q35. This finding was supported by meta-analysis of 20 other schizophrenia genome-wide scans that identified 5q23.2–q34 as the second most compelling susceptibility locus in the genome. In the present report, we took a two-stage candidate gene association approach to investigate a group of gamma-aminobutyric acid (GABA) A receptor subunit genes (GABRA1, GABRA6… CONTINUE READING
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