Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice

@inproceedings{Murdoch2014GeneticIB,
  title={Genetic interactions between planar cell polarity genes cause diverse neural tube defects in mice},
  author={Jennifer N. Murdoch and Christine Damrau and Anju Paudyal and Debora Bogani and Sara Wells and Nicholas D. E. Greene and Philip Stanier and Andrew J Copp},
  booktitle={Disease models & mechanisms},
  year={2014}
}
Neural tube defects (NTDs) are among the commonest and most severe forms of developmental defect, characterized by disruption of the early embryonic events of central nervous system formation. NTDs have long been known to exhibit a strong genetic dependence, yet the identity of the genetic determinants remains largely undiscovered. Initiation of neural tube closure is disrupted in mice homozygous for mutations in planar cell polarity (PCP) pathway genes, providing a strong link between NTDs and… CONTINUE READING
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