Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.

@article{Westphal1997GeneticIB,
  title={Genetic interactions between atm and p53 influence cellular proliferation and irradiation-induced cell cycle checkpoints.},
  author={Christoph H. Westphal and Cornelius Schmaltz and Sheldon Rowan and Ayano Elson and David E Fisher and Philip Leder},
  journal={Cancer research},
  year={1997},
  volume={57 9},
  pages={
          1664-7
        }
}
Ataxia-telangiectasia and Li-Fraumeni syndrome, pleiotropic disorders caused by mutations in the genes atm and p53, share a marked increase in cancer rates. A number of studies have argued for an interaction between these two genes (for comprehensive reviews, see M. S. Meyn, Cancer Res., 55: 5991-6001, 1995, and M. F. Lavin and Y. Shiloh, Annu. Rev., Immunol., 15: 177-202, 1996). Specifically, atm is placed upstream of p53 in mediating G1-S cell cycle checkpoint control, and both atm and p53… CONTINUE READING

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ATM: from gene to function.

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