Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.

@article{Neufeld2014GeneticIB,
  title={Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.},
  author={Stanley J Neufeld and Fan Wang and John N. Cobb},
  journal={Genetics},
  year={2014},
  volume={198 3},
  pages={1117-26}
}
The growth and development of the vertebrate limb relies on homeobox genes of the Hox and Shox families, with their independent mutation often giving dose-dependent effects. Here we investigate whether Shox2 and Hox genes function together during mouse limb development by modulating their relative dosage and examining the limb for nonadditive effects on growth. Using double mRNA fluorescence in situ hybridization (FISH) in single embryos, we first show that Shox2 and Hox genes have associated… CONTINUE READING
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