Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae.

@article{Venturi2000GeneticIB,
  title={Genetic interactions between GLC7, PPZ1 and PPZ2 in saccharomyces cerevisiae.},
  author={Guglielmo M. Venturi and Andrew Bloecher and Tara Williams-Hart and Kelly Tatchell},
  journal={Genetics},
  year={2000},
  volume={155 1},
  pages={69-83}
}
GLC7 encodes an essential serine/threonine protein type I phosphatase in Saccharomyces cerevisiae. Three other phosphatases (Ppz1p, Ppz2p, and Sal6p) share >59% identity in their catalytic region with Glc7p. ppz1 ppz2 null mutants have no apparent growth defect on rich media. However, null alleles of PPZ1 and PPZ2, in combination with mutant alleles of GLC7, confer a range of growth defects varying from slow growth to lethality. These results indicate that Glc7p, Ppz1p, and Ppz2p may have… CONTINUE READING