Genetic interactions and dosage effects of Polycomb group genes of Drosophila

@article{Campbell2004GeneticIA,
  title={Genetic interactions and dosage effects of Polycomb group genes of Drosophila},
  author={R. B. Campbell and D. Sinclair and Mitchell Couling and H. Brock},
  journal={Molecular and General Genetics MGG},
  year={2004},
  volume={246},
  pages={291-300}
}
The Polycomb (Pc) group of genes are required for maintenance of cell determination in Drosophila melanogaster. At least 11 Pc group genes have been described and there may be up to 40; all are required for normal regulation of homeotic genes, but as a group, their phenotypes are rather diverse. It has been suggested that the products of Pc group genes might be members of a heteromeric complex that acts to regulate the chromatin structure of target loci. We examined the phenotypes of adult… Expand
Cross-Regulation among the Polycomb Group Genes in Drosophila melanogaster
TLDR
Genes of the Polycomb group in Drosophila melanogaster function as long-term transcriptional repressors and there is positive regulation of PRC1 components by the ESC-E(Z) complex. Expand
Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.
TLDR
It is shown that PcG proteins can directly modulate cell growth in Drosophila, in part by regulating Thor expression, and chromatin immunoprecipitation evidence that P cG proteins are bound to the Thor 5' region in vivo is presented. Expand
Interactions amongst polycomb-group genes regulating flowering in Arabidopsis
Cell fate specification is one of the key aspects of development and is relatively wellcharacterised in plants. However, the mechanisms underlying the process is still rather poorly understood. InExpand
Polycomb Silencing of the Thor Gene
TLDR
It is reported that E(z) homozygotes also exhibit a cell growth defect; the cells comprising their small imaginal discs are also smaller than normal. Expand
In Vivo Regulation of E2F1 by Polycomb Group Genes in Drosophila
TLDR
It is found that depleting Su(z)2 in cultured Drosophila cells restores the cell-proliferation defects caused by reduction of d E2F1 by elevating the level of dE2f1. Expand
Additional Sex Combs-Like 2 Is Required for Polycomb Repressive Complex 2 Binding at Select Targets
TLDR
It is shown that the Asxl2-deficient heart is defective in converting H3k27me2 to H3K27me3 and in removing ubiquitin from mono-ubiquitinated histone H2A. Expand
The Drosophila pleiohomeotic mutation enhances the Polycomblike and Polycomb mutant phenotypes during embryogenesis and in the adult.
TLDR
Results provide genetic evidence of an interaction between PHO with other Polycomb group proteins at the embryonic and adult stages, and of the functioning of PHO as a component of the PcG complex. Expand
Biology of polycomb and trithorax group proteins.
TLDR
This review provides an overview of the genetics and molecular biology of the Polycomb and Trithorax group, concentrating mainly on mechanisms of Polycomb group-mediated repression. Expand
Coordinated regulation of Myc trans-activation targets by Polycomb and the Trithorax group protein Ash1
TLDR
Genetic, genomic and chromatin immunoprecipitation data suggest a model in which Pc, Ash1 and Pho are required to maintain a low level of expression of embryonic targets of activation by Myc, and that this occurs, directly or indirectly, by a combination of disparate chromatin modifications. Expand
Telomeric associated sequences of Drosophila recruit polycomb-group proteins in vivo and can induce pairing-sensitive repression.
TLDR
It is demonstrated that PcG proteins bind TASs in vivo and may be major players in Drosophila telomeric position effect (TPE). Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 50 REFERENCES
Screen for enhancers of Polycomb and Polycomblike in Drosophila melanogaster.
TLDR
Haploidy for four regions, 36F7-37A, 43E18; 44B5-9, 70C2-6, and 70C6-15; 70D enhanced the extra sex comb phenotype associated with strong Polycomb group mutations, and it is shown that spalt enhances PolyComb group mutations. Expand
Genetic analysis of the additional sex combs locus of Drosophila melanogaster.
TLDR
Analysis of embryonic and adult phenotypes of Asx alleles suggests that Asx is required zygotically for determination of segment number and polarity, and transposon-tagged the Asx gene is tagged, and can thus begin molecular analysis of its function. Expand
Dosage-dependent modifiers of polycomb and antennapedia mutations in Drosophila.
  • J. Kennison, J. Tamkun
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1988
TLDR
Two genes known to control the determination of segmental identity in Drosophila melanogaster are polycomb and antennapedia and four additional loci identified here have also been shown to have homoeotic phenotypes. Expand
The Polycomb group gene Posterior Sex Combs encodes a chromosomal protein.
TLDR
It is found that Psc RNA accumulates in developing oocytes and this maternal RNA is presumably responsible for the maternal rescue, indicating that the weak zygotic phenotype of Psc is due to maternal rescue. Expand
Maintenance of the engrailed expression pattern by Polycomb group genes in Drosophila.
TLDR
The data indicate that the same group of genes is required for stable restriction of en expression to a striped pattern and for the restriction of expression of homeotic genes along the anterior-posterior axis, and support a global role for the Pc group genes in stable repression of activity of developmental selector genes. Expand
Genetic interactions of the suppressor 2 of zeste region genes.
TLDR
It is reported here that the Pc group character of Psc is not due to a gain of function and presumably reflects the function of the wild-type gene, and evidence for a maternal function for Psc, as well as the neighboring Su(z)2 gene. Expand
The Polycomb protein shares a homologous domain with a heterochromatin-associated protein of Drosophila.
  • R. Paro, D. Hogness
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 1991
TLDR
The deduced sequence of the Pc protein exhibits a homology to the heterochromatin-associated protein HP1 encoded by the suppressor of position effect variegation gene Su(var) 205, suggesting that Pc could use analogous mechanisms at the level of the higher order chromatin structure for the stable transmission of a determined state. Expand
Related chromosome binding sites for zeste, suppressors of zeste and Polycomb group proteins in Drosophila and their dependence on Enhancer of zeste function.
TLDR
The results suggest that the binding of at least some Polycomb group proteins requires interactions with other members of the group and, although zeste can bind independently, its repressive effect on white involves the presence ofat least some of the PolyComb group proteins. Expand
Mutations in polycombeotic, a Drosophila polycomb-group gene, cause a wide range of maternal and zygotic phenotypes.
TLDR
It is reported that polycombeotic (formerly 1(3)1902), originally identified by a lethal mutation that causes a small-disc phenotype, is also a member of this group of essential genes. Expand
Polycomb and polyhomeotic are constituents of a multimeric protein complex in chromatin of Drosophila melanogaster.
TLDR
Using immunoprecipitation and double‐immunofluorescence labelling, it is shown that two members of the Pc‐G, Polycomb and polyhomeotic, are constituents of a soluble multimeric protein complex. Expand
...
1
2
3
4
5
...