Genetic instability of modified stem cells - a first step towards malignant transformation?

@article{Steinemann2013GeneticIO,
  title={Genetic instability of modified stem cells - a first step towards malignant transformation?},
  author={Doris Steinemann and Gudrun G{\"o}hring and Brigitte Schlegelberger},
  journal={American journal of stem cells},
  year={2013},
  volume={2 1},
  pages={39-51}
}
Induced pluripotent stem cells (iPSC) are important tools in regenerative medicine. Yet, it is becoming increasingly clear that the reprogramming process, including retroviral transduction with potent oncogenes like c-Myc and long-term cultivation, may induce genetic instability. Genetically altered iPS cells can grow out and dominate the cell culture. This review intends to comprehensively summarize the current knowledge on genetic instability of embryonic and iPSCs, with an emphasis on… CONTINUE READING

From This Paper

Topics from this paper.
9 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-9 of 9 extracted citations

Similar Papers

Loading similar papers…