Genetic instability is not a requirement for tumor development.

@article{Bodmer2008GeneticII,
  title={Genetic instability is not a requirement for tumor development.},
  author={Walter F. Bodmer and Jason H. Bielas and Robert A. Beckman},
  journal={Cancer research},
  year={2008},
  volume={68 10},
  pages={3558-60; discussion 3560-1}
}
The idea, originating in the early years of the 20th century, that each cancer is an independent somatic evolutionary process has been abundantly confirmed by modern molecular approaches (1–3). Genetic and epigenetic changes that increase the chance of outgrowth of the developing tumor are successively selected for. It has, however, often been argued that normal mutation rates are not sufficient to explain the number of steps that seem to be needed for giving rise to a cancer. This has led to… CONTINUE READING

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Genetic instability is not a requirement for tumor development

  • W Bodmer
  • Cancer Res
  • 2008

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