Genetic instability as the primary cause of human aging

@article{Strehler1986GeneticIA,
  title={Genetic instability as the primary cause of human aging},
  author={B. Strehler},
  journal={Experimental Gerontology},
  year={1986},
  volume={21},
  pages={283-319}
}
  • B. Strehler
  • Published 1986
  • Biology, Medicine
  • Experimental Gerontology
The origins of aging of higher forms of life, particularly humans, is presented as the consequence of an evolved balance between 4 specific kinds of dysfunction-producing events and 4 kinds of evolved counteracting effects in long-lived forms. Among the deleterious events, particular importance is assigned to damage to DNA, but damage of a different kind than classical mutations. The evolution in man's ancestors of means to counteract the kinds of events that limit the life-spans of short lived… Expand
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