Genetic instability as the primary cause of human aging

@article{Strehler1986GeneticIA,
  title={Genetic instability as the primary cause of human aging},
  author={Bernard L. Strehler},
  journal={Experimental Gerontology},
  year={1986},
  volume={21},
  pages={283-319}
}
  • B. Strehler
  • Published 31 December 1986
  • Biology
  • Experimental Gerontology

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References

SHOWING 1-10 OF 41 REFERENCES

Polygamy and the evolution of human longevity

  • B. Strehler
  • Biology
    Mechanisms of Ageing and Development
  • 1979

Loss of Genes coding for Ribosomal RNA in Ageing Brain Cells

Evidence is presented for the accumulation of single strand scissions in the DNA of ageing mouse neurones and an age-dependent increase in protein crosslinking that reflects damage to DNA accumulating during ageing.

Origin and Comparison of the Effects of Time and High-Energy Radiations on Living Systems

The evolutionary origin of the aging process and the nature of the possible sources of instability afford evidence that there are multiple causes of aging.

Experimental Studies on the Duration of Life. VII. The Mendelian Inheritance of Duration of Life in Crosses of Wild Type and Quintuple Stocks of Drosophila melanogaster

In this study, involving the determination of the duration of life of 5,415 individual flies, a cross was made between a long-lived stock of Drosophila (Old Falmouth, wild type) and a short-livedStock (Quintuple), with virtually identical mean duration oflife to those of the original parent stocks.