Genetic instability as the primary cause of human aging

  title={Genetic instability as the primary cause of human aging},
  author={Bernard L. Strehler},
  journal={Experimental Gerontology},
  • B. Strehler
  • Published 31 December 1986
  • Biology
  • Experimental Gerontology

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Genetic instability and aging: theories, facts, and future perspectives.

The results obtained to date do not rule out the possibility that genetic instability in a wide sense is a major causal factor in a number of age-related phenomena, but it appears that new strategies based on a new technology are ultimately necessary to elucidate the alterations in the intricately interwoven patterns of molecular control that could underlie the various aspects of the aging process.

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It is fair to conclude that aging in Drosophila may be viewed as a genetically-determined, environmentally-modulated, event-dependent process.

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Several types of diseases, among others autoimmune illnesses, could be coupled with the general processes of aging. The two-edged sword of immune defense is directed on one side against environmental



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The evolutionary origin of the aging process and the nature of the possible sources of instability afford evidence that there are multiple causes of aging.

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