Genetic instability, CpG island methylator phenotype, and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum.

@article{Nando2017GeneticIC,
  title={Genetic instability, CpG island methylator phenotype, and proliferative activity are distinct differences between diminutive and small tubular adenoma of the colorectum.},
  author={Yoshiki Nando and Jiro Watari and Chiyomi Ito and Ken Hara and Takahisa Yamasaki and Takuya Okugawa and Takaya Kondo and Tomoaki Kono and Katsuyuki Tozawa and Toshihiko Tomita and Yoshio Ohda and Tadayuki Oshima and Hirokazu Fukui and Nagahide Matsubara and Naohiro Tomita and Seiichi Hirota and Hiroto Miwa},
  journal={Human pathology},
  year={2017},
  volume={60},
  pages={
          37-45
        }
}
It is recommended that small (6-10 mm) lesions be treated with endoscopic resection (ER), whereas diminutive (≤5 mm) lesions are not currently an indication for ER according to the Japanese guidelines. The aim of this study was to evaluate the molecular alterations, and therefore treatment indications, in diminutive versus small tubular adenoma (TA). We prospectively analyzed genetic instability, including microsatellite instability and loss of heterozygosity, methylation status, KRAS/BRAF… CONTINUE READING