Genetic influences on the retention of inorganic mercury.

  title={Genetic influences on the retention of inorganic mercury.},
  author={Hipolito M Custodio and Ra{\'u}l Harari and Lars Gerhardsson and Staffan Skerfving and Karin Broberg},
  journal={Archives of environmental & occupational health},
  volume={60 1},
Mercury is eliminated as glutathione (GSH) conjugates. GSH production is mediated by glutamyl-cysteine ligase (GCL), and conjugation by glutathione S-transferases (GST). This study tested if polymorphisms in GCL and GST genes modify mercury retention in humans exposed to elemental mercury vapor. Total mercury concentrations in whole blood, plasma and urine, and genotypes for GCLC, GCLM, GSTA1, GSTM1, GSTP1, and GSTT1 were determined in 309 gold miners, gold buyers and controls. The presence of… CONTINUE READING
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