• Biology, Psychology, Medicine
  • Published in Nature Neuroscience 2016
  • DOI:10.1038/nn.4228

Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies

@inproceedings{Franke2016GeneticIO,
  title={Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof-of-concept and roadmap for future studies},
  author={Barbara Franke and Jason L. Stein and Stephan Ripke and Verneri Anttila and Derrek P Hibar and Kimm J E van Hulzen and Alejandro Arias-Vasquez and Jordan W. Smoller and Thomas E. Nichols and Michael C. Neale and Andrew M. McIntosh and Phil H. Lee and Francis J. McMahon and Andreas Meyer-Lindenberg and Manuel Mattheisen and Ole Andreas Andreassen and Oliver Gruber and Perminder Singh Sachdev and Roberto Roiz-Santia{\~n}ez and Andrew J. Saykin and Stefan Ehrlich and Karen Mather and Jessica A. Turner and Emanuel Schwarz and Anbupalam Thalamuthu and Yin Yao Shugart and Yvonne Y W Ho and Nicholas G. Martin and Margaret J. Wright and Michael C. O'Donovan and Paul M. Thompson and Benjamin M. Neale and Sarah E. Medland and Patrick F. Sullivan},
  booktitle={Nature Neuroscience},
  year={2016}
}
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain… CONTINUE READING

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