• DOI:10.1016/j.neulet.2005.05.067
Corpus ID: 23642220

Genetic influences on oxidative stress and their association with normal cognitive ageing

@article{Kachiwala2005GeneticIO,
  title={Genetic influences on oxidative stress and their association with normal cognitive ageing},
  author={Swati J. Kachiwala and S. Harris and A. F. Wright and C. Hayward and I. Deary},
  journal={Neuroscience Letters},
  year={2005},
  volume={386},
  pages={116-120}
}

Swati J. Kachiwala, S. Harris, +2 authors I. Deary

Published 2005

Biology, Medicine

Neuroscience Letters

Oxidative stress is hypothesised to play a major role in ageing processes. Reactive oxygen species produced during normal aerobic metabolism damage cellular macromolecules. The brain is particularly susceptible to oxidative stress due to its high rate of aerobic metabolism. We hypothesised that polymorphisms in genes contributing to antioxidant defences are associated with variation in normal cognitive ageing in the absence of dementia. We examined associations between two SNPs (rs2073495 and… CONTINUE READING

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