Genetic influences on oxidative stress and their association with normal cognitive ageing
@article{Kachiwala2005GeneticIO, title={Genetic influences on oxidative stress and their association with normal cognitive ageing}, author={Swati J. Kachiwala and S. Harris and A. F. Wright and C. Hayward and I. Deary}, journal={Neuroscience Letters}, year={2005}, volume={386}, pages={116-120} }
Oxidative stress is hypothesised to play a major role in ageing processes. Reactive oxygen species produced during normal aerobic metabolism damage cellular macromolecules. The brain is particularly susceptible to oxidative stress due to its high rate of aerobic metabolism. We hypothesised that polymorphisms in genes contributing to antioxidant defences are associated with variation in normal cognitive ageing in the absence of dementia. We examined associations between two SNPs (rs2073495 and… CONTINUE READING
Topics from this paper
51 Citations
A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition
- Biology, Medicine
- BMC Genetics
- 2007
- 68
- PDF
Oxidative stress and genetic markers of suboptimal antioxidant defense in the aging brain: a theoretical review
- Medicine, Biology
- Reviews in the neurosciences
- 2014
- 54
Contribution of genetic polymorphisms on functional status at very old age: A gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway
- Biology, Medicine
- Experimental Gerontology
- 2014
- 18
- PDF
Genetic determinants of ageing processes and diseases in later life.
- Biology, Medicine
- Maturitas
- 2009
- 17
The Impact of Genetic Research on our Understanding of Normal Cognitive Ageing: 1995 to 2009
- Psychology, Medicine
- Neuropsychology Review
- 2009
- 101
The association between telomere length, physical health, cognitive ageing, and mortality in non-demented older people
- Psychology, Medicine
- Neuroscience Letters
- 2006
- 181
Replication study of candidate genes for cognitive abilities: the Lothian Birth Cohort 1936
- Psychology, Medicine
- Genes, brain, and behavior
- 2009
- 87
Healthy cognitive ageing in the Lothian Birth Cohort studies: marginal gains not magic bullet.
- Medicine, Psychology
- Psychological medicine
- 2018
- 23
- PDF
The brain-derived neurotrophic factor Val66Met polymorphism is associated with age-related change in reasoning skills
- Psychology, Medicine
- Molecular Psychiatry
- 2006
- 165
- PDF
References
SHOWING 1-10 OF 43 REFERENCES
Evidence of increased oxidative damage in subjects with mild cognitive impairment
- Psychology, Medicine
- Neurology
- 2005
- 487
- PDF
Mechanisms of aging: an appraisal of the oxidative stress hypothesis.
- Biology, Chemistry
- Free radical biology & medicine
- 2002
- 601
Nicastrin gene polymorphisms, cognitive ability level and cognitive ageing
- Psychology, Medicine
- Neuroscience Letters
- 2005
- 26
Polymorphism of the prion protein is associated with cognitive impairment in the elderly
- Biology, Medicine
- Neurology
- 1998
- 75
Early cognitive decline is associated with prion protein codon 129 polymorphism
- Biology, Medicine
- Annals of neurology
- 2003
- 42
Neurodegenerative diseases and oxidative stress
- Biology, Medicine
- Nature Reviews Drug Discovery
- 2004
- 2,664
Searching for genetic influences on normal cognitive ageing
- Psychology, Medicine
- Trends in Cognitive Sciences
- 2004
- 82
M129V variation in the prion protein may influence cognitive performance
- Psychology, Medicine
- Molecular Psychiatry
- 2003
- 41
- PDF
Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress
- Biology, Medicine
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- 2003
- 228
The 129 codon polymorphism of the Prion Protein gene influences earlier cognitive performance in Down syndrome subjects
- Biology, Medicine
- Journal of Neurology
- 2003
- 33