Genetic influences on oxidative stress and their association with normal cognitive ageing

  title={Genetic influences on oxidative stress and their association with normal cognitive ageing},
  author={Swati J. Kachiwala and S. Harris and A. F. Wright and C. Hayward and I. Deary},
  journal={Neuroscience Letters},
  • Swati J. Kachiwala, S. Harris, +2 authors I. Deary
  • Published 2005
  • Biology, Medicine
  • Neuroscience Letters
  • Oxidative stress is hypothesised to play a major role in ageing processes. Reactive oxygen species produced during normal aerobic metabolism damage cellular macromolecules. The brain is particularly susceptible to oxidative stress due to its high rate of aerobic metabolism. We hypothesised that polymorphisms in genes contributing to antioxidant defences are associated with variation in normal cognitive ageing in the absence of dementia. We examined associations between two SNPs (rs2073495 and… CONTINUE READING
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