Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction

@article{Kreek2005GeneticIO,
  title={Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction},
  author={Mary Jeanne Kreek and David A. Nielsen and Eduardo R Butelman and K. Steven LaForge},
  journal={Nature Neuroscience},
  year={2005},
  volume={8},
  pages={1450-1457}
}
Genetic variation may partially underlie complex personality and physiological traits—such as impulsivity, risk taking and stress responsivity—as well as a substantial proportion of vulnerability to addictive diseases. Furthermore, personality and physiological traits themselves may differentially affect the various stages of addiction, defined chronologically as initiation of drug use, regular drug use, addiction/dependence and potentially relapse. Here we focus on recent approaches to the… 

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References

SHOWING 1-10 OF 65 REFERENCES

Opiates, opioids and addiction.

  • M. Kreek
  • Psychology, Medicine
    Molecular psychiatry
  • 1996
TLDR
This work has addressed the research question related to the early hypotheses on the development of an addiction, that atypical responsitivity to stress and stressors may play a central role in the acquisition and persistence of, and relapse to, drug abuse.

Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene.

TLDR
Evidence of a gene-by-environment interaction is provided, in which an individual's response to environmental insults is moderated by his or her genetic makeup.

Substance abuse vulnerability loci: converging genome scanning data.

Substance abuse vulnerability and D2 receptor genes

Pharmacogenetics and Human Molecular Genetics of Opiate and Cocaine Addictions and Their Treatments

TLDR
The molecular genetics and pharmacogenetics of opiate and cocaine addictions are reviewed, focusing primarily on genes of the opioid and monoaminergic systems that have been associated with or have evidence for linkage to opiate or cocaine addiction.

Specificity of genetic and environmental risk factors for use and abuse/dependence of cannabis, cocaine, hallucinogens, sedatives, stimulants, and opiates in male twins.

TLDR
In an adult population-based sample of male twins, both the genetic and the shared environmental effects on risk for the use and misuse of six classes of illicit substances were largely or entirely nonspecific in their effect.

Genetic and Environmental Influences on Transitions in Drug Use

Genetic and environmental factors influence drug abuse, but abuse represents the culmination of a sequence of events. Different levels of use may have different determinants and these determinants

Pharmacotherapy of addictions

TLDR
The current approved and implemented pharmacotherapeutic approaches to the treatment of addiction are summarized, and the most promising areas for future drug development are highlighted from the perspective of the laboratory and NIDA Research Center.

Co-occurrence of abuse of different drugs in men: the role of drug-specific and shared vulnerabilities.

TLDR
Evidence is found for a shared or common vulnerability factor that underlies the abuse of marijuana, sedatives, stimulants, heroin or opiates, and psychedelics that is influenced by genetic, family environmental, and nonfamily environmental factors.
...