• DOI:10.1007/BF01436001
Corpus ID: 25976832

Genetic influences on glucose neurotoxicity, aging, and diabetes: A possible role for glucose hysteresis

@article{Mobbs2005GeneticIO,
  title={Genetic influences on glucose neurotoxicity, aging, and diabetes: A possible role for glucose hysteresis},
  author={C. Mobbs},
  journal={Genetica},
  year={2005},
  volume={91},
  pages={239-253}
}

• C. Mobbs
• Published 2005
• Biology, Medicine
• Genetica

Glucose may drive some age-correlated impairments and may mediate some effects of dietary restriction on senescence. The hypothesis that cumulative deleterious effects of glucose may impair hypothalamic neurons during aging, leading to hyperinsulinemia and other age-correlated pathologies, is examined in the context of genetic influences. Susceptibility to toxic effects of gold-thio-glucose (GTG) is correlated with longevity across several mouse strains. GTG and chronic hyperglycemia induce… Expand

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