Genetic influences on cellular reactions to spinal cord injury: a wound-healing response present in normal mice is impaired in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration.

@article{Zhang1996GeneticIO,
  title={Genetic influences on cellular reactions to spinal cord injury: a wound-healing response present in normal mice is impaired in mice carrying a mutation (WldS) that causes delayed Wallerian degeneration.},
  author={Zhenguo Zhang and Minoru Fujiki and Lloyd Guth and Oswald Steward},
  journal={The Journal of comparative neurology},
  year={1996},
  volume={371 3},
  pages={485-95}
}
Progressive tissue necrosis is a process unique to the injured mammalian spinal cord which often leads to gradually increasing cavitation and enlargement of the lesion. To evaluate the role of neuronal degeneration in initiating this response, histopathological changes were compared in C57BL and WldS (delayed Wallerian degeneration mutation) mice. The spinal cord was crushed at T8, producing a primary lesion at the site of the trauma and a secondary lesion extending rostrocaudally in the dorsal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

A graded forceps crush spinal cord injury model in mice.

Journal of neurotrauma • 2008
View 7 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…