Genetic influences in opioid analgesic sensitivity in mice.

  title={Genetic influences in opioid analgesic sensitivity in mice.},
  author={Chaim Gideon Pick and Jianjun Cheng and Dennis Paul and Gavril W Pasternak},
  journal={Brain research},
  volume={566 1-2},
Studies of various strains of mice revealed marked differences in their analgesic sensitivity towards morphine (mu), U50,488H (kappa 1) and naloxone benzoylhydrazone (NalBzoH; kappa 3). Sensitivity to mu and kappa analgesia varied independently of the other. Analgesic sensitivity to morphine remained relatively consistent among 3 different nociceptive assays for each strain. However, the sensitivity of an individual strain to NalBzoH remained highly dependent upon the assay used. CD-1 mice were… CONTINUE READING